![]() This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This project was financed by intramural funds and resources provided by the University of Leipzig and the Fraunhofer-Institute of Cell Therapy and Immunology. ![]() Received: NovemAccepted: FebruPublished: April 15, 2014Ĭopyright: © 2014 Hoffmann et al. PLoS ONE 9(4):Įditor: Piotr Walczak, Johns Hopkins University, United States of America (2014) The Ovine Cerebral Venous System: Comparative Anatomy, Visualization, and Implications for Translational Research. Moreover, it features a comprehensive interspecies-comparison of the venous cerebral angioarchitecture in man, rodents, canines and sheep as a relevant large animal model species, and describes possible implications for translational cerebrovascular research.Ĭitation: Hoffmann A, Stoffel MH, Nitzsche B, Lobsien D, Seeger J, Schneider H, et al. This report provides a detailed reference for the interpretation of venous diagnostic imaging findings in sheep, including an assessment of structure detectability by in vivo (imaging) versus ex vivo (corrosion cast) visualization methods. For the first time, we also describe venous confluences in the deep cerebral venous system and an ‘anterior condylar confluent’ as seen in humans. In particular, we provide evidence for chordae Willisii and lateral venous lacunae, and report on connections between the dorsal and ventral sinuses in this species. ![]() This combined approach yielded detailed and, to some extent, novel findings. We used corrosion casts as well as contrast-enhanced magnetic resonance venography to scrutinize blood drainage from the brain. The present study was intended to provide a comprehensive anatomical analysis of the intracranial venous system in sheep as a reliable basis for the interpretation of experimental results in such ovine models. Ovine stroke models may represent a promising approach but are currently limited by insufficient knowledge regarding the venous system of the cerebral angioarchitecture. Improvements in diagnostic and therapeutic approaches strongly rely on adequate gyrencephalic, large animal models being demanded for translational research. Cerebrovascular diseases are significant causes of death and disability in humans.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |